Den Bosch is in general a safe city. Even the neighborhoods considered dangerous by the locals are still quite safe during daylight Hambaken, Graafsewijk and Kruiskamp. If a traveler uses his common sense he will be alright, also during night. The only time the crowd can get a bit rough is during Thursday, Friday and Saturday night. These are the general party nights, so people sometimes drink too much. Nevertheless, there is a lot of police around, and you will be safe if you just take care and mind your own business.